ITADN

Expand minimalInformative and Quantiles2LogisticNormal functions to work also for LogisticLogNormalSub

#934OpendimitriskontosBAY 创建于 2026-03-04
enhancementhigh priority
**Summary** As far as I understand the idea of [MinimalInformative](https://docs.crmpack.org/main/reference/MinimalInformative.html) and [Quantiles2LogisticNormal](https://docs.crmpack.org/main/reference/Quantiles2LogisticNormal.html) originates from the content in Neuenschwander B, Branson M, Gsponer T (2008). “Critical aspects of the Bayesian approach to phase I cancer trials.” Statistics in Medicine, 27(13), 2420–2439. [https://onlinelibrary.wiley.com/doi/10.1002/sim.3230](https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.1002%2Fsim.3230&data=05%7C02%7C%7C6294463b1fa6410af5f408de7926f11c%7Cfcb2b37b5da0466b9b830014b67a7c78%7C0%7C0%7C639081405426616541%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=UetxYBrpPXiDpP0oatVLXTN9yq5047vbSzLvtdroxjo%3D&reserved=0). APPENDIX A: PRIOR SPECIFICATIONSA.1. Quantile-based non-informative (default) prior As a consequence I understand that in the current version of the cmrPack, this idea in implemented currently assuming [LogisticNormal](https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.crmpack.org%2Fmain%2Freference%2FLogisticNormal-class.html&data=05%7C02%7C%7C6294463b1fa6410af5f408de7926f11c%7Cfcb2b37b5da0466b9b830014b67a7c78%7C0%7C0%7C639081405426630281%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=W2cczUwKELIIAFMEeuZUwDHQmw32p7VRcZ7spM8yt6Q%3D&reserved=0) (or [LogisticLogNormal](https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.crmpack.org%2Fmain%2Freference%2FLogisticLogNormal-class.html&data=05%7C02%7C%7C6294463b1fa6410af5f408de7926f11c%7Cfcb2b37b5da0466b9b830014b67a7c78%7C0%7C0%7C639081405426643133%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=7j9MmDWuopsSfvVX4g4grJUp8S58pErfgWDgWoTTwDc%3D&reserved=0)) object. So I am wondering if crmPack [MinimalInformative](https://docs.crmpack.org/main/reference/MinimalInformative.html) / [Quantiles2LogisticNormal](https://docs.crmpack.org/main/reference/Quantiles2LogisticNormal.html) functionality could be expanded to be able to apply also for a [LogisticLogNormalSub](https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcran.r-project.org%2Fweb%2Fpackages%2FcrmPack%2Frefman%2FcrmPack.html%23topic%2BLogisticLogNormalSub&data=05%7C02%7C%7C6294463b1fa6410af5f408de7926f11c%7Cfcb2b37b5da0466b9b830014b67a7c78%7C0%7C0%7C639081405426655895%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=7M691GKw89n0gbshFfsgatyBdGrQm95KG6m9FOwQkSU%3D&reserved=0) class That would be useful to have since within Bayer we currently mainly working with logit[p(x)]=alpha0+alpha1∗(x), parametrization of the logistic model **Additional Information** NA
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