dataverse 10.18130 V3 F3TD5R tab terms d4d

Description This dataset is the June 2025 Data Release of Cell Maps for Artificial Intelligence (CM4AI; CM4AI.org), the Functional Genomics Grand Challenge in the NIH Bridge2AI program. This Beta release includes perturb-seq data in undifferentiated KOLF2.1J iPSCs; SEC-MS data in undifferentiated KOLF2.1J iPSCs, iPSC-derived NPCs, neurons, cardiomyocytes, and treated and untreated MDA-MB468 breast cancer cells; and IF images in MDA-MB-468 breast cancer cells in the presence and absence of chemotherapy (vorinostat and paclitaxel). External Data Links Access external data resources related to this dataset: Sequence Read Archive (SRA) Data: NCBI BioProject Mass Spectrometry Data (Human iPSCs): MassIVE Repository Mass Spectrometry Data (Human Cancer Cells): MassIVE Repository Data Governance & Ethics Human Subjects: No De-identified Samples: Yes FDA Regulated: No Data Governance Committee: Jillian Parker (jillianparker@health.ucsd.edu) Ethical Review: Vardit Ravitsky (ravitskyv@thehastingscenter.org) and Jean-Christophe Belisle-Pipon (jean-christophe_belisle-pipon@sfu.ca) Completeness These data are not yet in completed final form: Some datasets are under temporary pre-publication embargo Protein-protein interaction (SEC-MS), protein localization (IF imaging), and CRISPRi perturbSeq data interrogate sets of proteins which incompletely overlap Computed cell maps not included in this release Maintenance Plan Dataset will be regularly updated and augmented through the end of the project in November 2026 Updates on a quarterly basis Long term preservation in the University of Virginia Dataverse, supported by committed institutional funds Intended Use This dataset is intended for: AI-ready datasets to support research in functional genomics AI model training Cellular process analysis Cell architectural changes and interactions in presence of specific disease processes, treatment conditions, or genetic perturbations Limitations Researchers should be aware of inherent limitations: This is an interim release Does not contain predicted cell maps, which will be added in future releases The current release is most suitable for bioinformatics analysis of the individual datasets Requires domain expertise for meaningful analysis Prohibited Uses These laboratory data are not to be used in clinical decision-making or in any context involving patient care without appropriate regulatory oversight and approval Potential Sources of Bias Users should be aware of potential biases: Data in this release was derived from commercially available de-identified human cell lines Does not represent all biological variants which may be seen in the population at large