EndoTag-AP-MS Profiling of Chromatin Modifier Interactome Rewiring in MDA-MB-468 Cells Upon Vorinostat Perturbation

Version 1.0 License ↗ Released 2026-05-22T13:58:58.942348+00:00

RO-Crate Summary

ROCrate ID
Release Date
2026-05-22T13:58:58.942348+00:00
Description
This submission comprises affinity purification mass spectrometry (AP-MS) raw data generated from endogenously tagged MDA-MB-468 cells under Vorinostat perturbation. The dataset focuses on drug-induced interactome rewiring of chromatin modifiers relevant to the triple-negative breast cancer context. All AP-MS experiments were performed in four biological replicates. Each AP-MS batch includes an untagged parental control, 10 chromatin modifier tagged cell lines, and a positive control tagged line. DMSO-treated sample server as vehicle controls across all AP-MS experiments (Unpublished data).
Authors
Richa Tiwari
Principal Investigator
Trey Ideker
Contact Email
tideker@health.ucsd.edu
License
Confidentiality Level
Unrestricted
Keywords
proteomics, mass spectrometry, MassIVE, EndoTagging, AP-MS, Triple Negative Breast Cancer, MDA-MB-468, Vorinostat, CM4AI, Bridge2AI
Citation
Clark T; Parker J; Al Manir S; Axelsson U; Ballllosero Navarro F; Chinn B; Churas CP; Dailamy A; Doctor Y; Fall J; Forget A; Gao J; Hansen JN; Hu M; Johannesson A; Khaliq H; Lee YH; Lenkiewicz J; Levinson MA; Metallo C; Muralidharan M; Nourreddine S; Niestroy J; Obernier K; Pan E; Park, S; Polacco B; Pratt D; Qian G; Schaffer, LV; Sigaeva A; Thaker S; Zhang Y; Zhao, X; Bélisle-Pipon JC; Brandt C; Chen JY; Ding Y; Fodeh S; Krogan N; Lundberg E; Mali P; Payne-Foster P; Ratcliffe S; Ravitsky V; Sali A; Schulz W; Ideker T, 2025, "Cell Maps for Artificial Intelligence - March 2025 Data Release (Beta)", https://doi.org/10.18130/V3/K7TGEM , https://dataverse.lib.virginia.edu/, V1
Datasets 718
Samples 138
Experiments 139
Instruments 1
Schemas 2
Name Description Access Release Date
README_MassIVEdatarelease_Vorinostat_APMS.pdf PDF from MassIVE MSV000101917 at methods/README_MassIVEdatarelease_Vorinostat_APMS.pdf. Access / Download 2026-05-22T13:58:58.942348+00:00
parameters.txt TXT from MassIVE MSV000101917 at search/parameters.txt. Access / Download 2026-05-22T13:58:58.942348+00:00
202209_uniprot_human_reviewed_Original_one.fasta FASTA from MassIVE MSV000101917 at search/202209_uniprot_human_reviewed_Original_one.fasta. Access / Download 2026-05-22T13:58:58.942348+00:00
summary.tsv TSV from MassIVE MSV000101917 at ccms_metadata/summary.tsv. Access / Download 2026-05-22T13:58:58.942348+00:00
APMS_Vorinostat_Sample_Annotation.tsv TSV from MassIVE MSV000101917 at metadata/APMS_Vorinostat_Sample_Annotation.tsv. Access / Download 2026-05-22T13:58:58.942348+00:00
params.xml XML from MassIVE MSV000101917 at ccms_parameters/params.xml. Access / Download 2026-05-22T13:58:58.942348+00:00
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