# CM4AI all combined d4d

Datasheet for Dataset - Human Readable Format

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## Collection Process

How was the data acquired?

ID *
cm4ai-2025-beta-data-releases
Name
CM4AI 2025 Beta Data Releases
Title
Cell Maps for Artificial Intelligence (CM4AI) - 2025 Beta Data Releases
Description
Combined documentation for the March 2025 and June 2025 Beta data releases of Cell Maps for Artificial Intelligence (CM4AI; CM4AI.org), the Functional Genomics Grand Challenge in the NIH Bridge2AI program. These releases include: (a) perturb-seq data in undifferentiated KOLF2.1J human induced pluripotent stem cells (hiPSCs); (b) protein-protein interaction data generated by size exclusion chromatography mass spectrometry (SEC-MS) across undifferentiated KOLF2.1J hiPSCs and iPSC-derived NPCs, neurons, cardiomyocytes, and treated and untreated MDA-MB-468 breast cancer cells; and (c) immunofluorescence (IF) images of subcellular protein localization in MDA-MB-468 cells in the presence and absence of chemotherapy (vorinostat and paclitaxel). CM4AI output data are packaged as AI-ready datasets in RO-Crate format using the FAIRSCAPE framework, with provenance graphs and rich metadata. Data are augmented regularly through the end of the project (planned November 2026). Collaboration includes UC San Diego, UC San Francisco, Stanford University, University of Virginia, Yale University, University of Alabama at Birmingham, Simon Fraser University, and The Hastings Center. Copyright (c) 2025 The Regents of the University of California except where otherwise noted. Spatial proteomics raw image data is Copyright (c) 2025 The Board of Trustees of the Leland Stanford Junior University. Dataset licensed for reuse under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Created On
2025-02-27
Issued
2025-03-03
Keywords

- AI
- artificial intelligence
- machine learning
- Bridge2AI
- CM4AI
- CRISPR/Cas9
- perturb-seq
- perturbation sequencing
- single-cell RNA sequencing
- scRNAseq
- induced pluripotent stem cell
- iPSC
- KOLF2.1J
- protein-protein interaction
- SEC-MS
- size exclusion chromatography
- mass spectroscopy
- affinity purification
- AP-MS
- protein localization
- subcellular imaging
- breast cancer
- MDA-MB-468
- neural progenitor cell
- NPC
- neuron
- cardiomyocyte
- paclitaxel
- vorinostat

Resources

Role | Name | ORCID | Affiliation
--- | --- | --- | ---
Contributor | CM4AI March 2025 Data Release (Beta) | doi:10.18130/V3/B35XWX | -
Contributor | CM4AI June 2025 Data Release (Beta) | doi:10.18130/V3/F3TD5R | -

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## Distribution

How will the dataset be distributed?

License
CC BY-NC-SA 4.0
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## Maintenance

How will the dataset be maintained?

Last Updated On
2025-07-01
Generated on 2025-11-09 10:17:34 using Bridge2AI Data Sheets Schema