National Institutes of Health (NIH) Bridge2AI program
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Response
March 2025 data release of CM4AI (the NIH Bridge2AI Functional Genomics Grand Challenge), providing AI-ready multimodal cellular datasets (perturb-seq, SEC-MS, and immunofluorescence imaging) packaged with provenance and rich metadata.
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Composition
What do the instances represent?
Data Type
Representation
perturb-seq data
perturb-seq data in undifferentiated KOLF2.1J iPSCs
SEC-MS data
SEC-MS data in undifferentiated KOLF2.1J iPSCs and iPSC-derived NPCs, neurons, and cardiomyocytes
immunofluorescence images
IF images in MDA-MB-468 breast cancer cells in the presence and absence of chemotherapy (vorinostat ...
Cell Maps for Artificial Intelligence - March 2025 Data Release (Beta)
Cell Maps for Artificial Intelligence - March 2025 Data Release (Beta)
This dataset is the March 2025 Data Release of Cell Maps for Artificial Intelligence (CM4AI; CM4AI.org), the Functional Genomics Grand Challenge in the NIH Bridge2AI program. This Beta release includes perturb-seq data in undifferentiated KOLF2.1J iPSCs; SEC-MS data in undifferentiated KOLF2.1J iPSCs and iPSC-derived NPCs, neurons, and cardiomyocytes; and IF images in MDA-MB-468 breast cancer cells in the presence and absence of chemotherapy (vorinostat and paclitaxel). CM4AI output data are packaged with provenance graphs and rich metadata as AI-ready datasets in RO-Crate format using the FAIRSCAPE framework. Data presented here will be augmented regularly through the end of the project. CM4AI is a collaboration of UCSD, UCSF, Stanford, UVA, Yale, UA Birmingham, Simon Fraser University, and the Hastings Center. This data is Copyright (c) 2025 The Regents of the University of California except where otherwise noted. Spatial proteomics raw image data is copyright (c) 2025 The Board of Trustees of the Leland Stanford Junior University. Dataset licensed for reuse under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license (https://creativecommons.org/licenses/by-nc-sa/4.0/). Attribution is required to the copyright holders and the authors. Any publications referencing this data or derived products should cite the Related Publication below, as well as directly citing this data collection (2025-03-04).
IF images in MDA-MB-468 breast cancer cells with and without chemotherapy (vorinostat and paclitaxel...
Immunofluorescence images (MDA-MB-468)
Description
Copyright (c) 2025 The Regents of the University of California except where otherwise noted.
Spatial proteomics raw image data is copyright (c) 2025 The Board of Trustees of the Leland Stanford Junior University.
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Uses
What (other) tasks could the dataset be used for?
Description
Dataset licensed for reuse under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license (https://creativecommons.org/licenses/by-nc-sa/4.0/).
Attribution is required to the copyright holders and the authors.
Any publications referencing this data or derived products should cite the Related Publication and directly cite this data collection (2025-03-04).