Test

## [1] "NextBestThreePlusThree"

The dose recommended for the next cohort will be chosen using the “Three Plus Three” rule.

• If no toxicities have been reported at the current dose level, escalate by one dose level.
• If the observed toxicity rate at the current dose level is exactly 1/3 and no more than three participants treated at the current dose level are evaluable, remain at the current dose level.
• Otherwise, recommend that the trial stops and identify the MTD as dose level immediately below the current one.