## [1] "NextBestNCRMLoss"
The dose recommended for the next cohort will be chosen in the
following way:
- First, the chance that the probability of toxicity falls into each
of the underdose, target , overdose and unacceptable dose ranges is
calculated for element of the dose grid.
- Next, the loss associated with each dose is calculated by
multiplying these probabilities by the corresponding loss coefficient
and summing the result.
- Then ineligible doses, and those with a probability of being in the
overdose or unaccaptable ranges that is greater than 0.25, are
discarded.
- Finally, the dose level with the smallest loss is selected as the
recommended dose for the next cohort.
Toxicity ranges and loss coefficients are given in the following
table:
|
Range
|
Lower
|
Upper
|
Loss Coefficient
|
|
Underdose
|
0.00
|
0.20
|
1
|
|
Target
|
0.20
|
0.35
|
0
|
|
Overdose
|
0.35
|
0.60
|
1
|
|
Unacceptable
|
0.60
|
1.00
|
2
|