Test

## [1] "NextBestMTD"

The dose level recommended for the next cohort will be selected as follows:

• First, the 25th centile of the posterior distribution of toxicity will be calculated for all dose levels that are eligible according to the Increments rule.
• Next, the “target dose” (which may not be part of the dose grid) for which the 25th centile of the posterior distribution of toxicity is exactly equal to the target rate of 0.33 will be determined.
• Finally, the dose level whose absolute distance from the target dose is smallest will be selected as the recommended dose for the next cohort