Test

## [1] "NextBestInfTheory"

The recommended dose for the next cohort will be chosen using the complex infinite bounds penalisation (CIBP) criterion of Mozgunov & Jaki (2019). Let

\[ \delta(\hat{p}_d, \gamma) = \frac{(\hat{p}_d - \gamma)^2}{\hat{p}_d^a \cdot (1 - \hat{p}_d)^{2 - a}} \]

where a is the non-centrality parameter with a value of 1.2, γ is the target toxicity rate with a value of 0.33 and \(\hat{p}_d\) is the mean posterior estimate of the probability of toxicity at dose level d.

The recommended dose for the next cohort will be the value of d that minimises \(\delta(\hat{p}_d, \gamma)\).