Test

## [1] "NextBestDualEndpoint"

The dose recommended for the next cohort will be chosen in the following way. First, doses that are ineligible according to the increments rule will be discarded. Next, any dose for which the mean posterior probability of toxicity being in the overdose range - (0.35, 1] - is 0.25 or more will also be discarded. Finally, the dose amongst those remaining which has the highest chance that the mean posterior probability that the biomarker is in the target range for the biomarker, which is 200 to 300 (inclusive), will be selected, provided that this probability exceeds 0.01. If no dose meets this threshold, then the highest eligible dose will be selected.