## [1] "IncrementsRelativeParts"
## attr(,"package")
## [1] "crmPack"
The maximum increment in Part 1 is defined by the
part1Ladder slot of the associated DataParts
object.
If no toxicities are reported in Part 1, the starting dose for Part 2 will be the highest dose used in Part 1.
If one or more toxicities are reported in Part 1, the starting dose for Part 2 will be 1 dose below the highest dose used in Part 1.
Once Part 2 has started, the maximum increment in dose levels will be based on the number of toxicities reported so far, as described in the following table:| Lower | Upper | Increment |
|---|---|---|
| -Inf | 0 | 0 |
| 0 | 2 | 2 |
| 2 | Inf | 1 |