OVERVIEW
Expression Analysis Summary
Summary of differential expression analysis results from fluoxetine-treated NSCLC cell lines.
12,847
Total Genes
after filtering
342
Upregulated
padj < 0.05, log2FC > 1
287
Downregulated
padj < 0.05, log2FC < -1
4.8%
DEG Rate
629 / 12,847
Key Finding
Fluoxetine treatment induces significant ER stress response, with DDIT3 and ATF4 among the top upregulated genes (log2FC > 2.5). The unfolded protein response (UPR) pathway shows coordinated activation across multiple effectors, suggesting a potential mechanism for NSCLC cell growth inhibition.
Evidence
High Confidence
3 Studies
VISUALIZATION
Volcano Plot
Log2 fold change vs. statistical significance for all genes.
Volcano Plot
Red = upregulated, Blue = downregulated, Gray = not significant
CORTEX
DATA
Top Differentially Expressed Genes
Ranked by adjusted p-value. Click column headers to sort.
| Gene ↕ | log2FC ↕ | padj ↕ | baseMean ↕ | Direction ↕ |
|---|---|---|---|---|
| DDIT3 | 3.42 | 1.2e-15 | 892 | Up |
| ATF4 | 2.87 | 4.5e-12 | 1204 | Up |
| HSPA5 | 2.31 | 2.1e-10 | 3421 | Up |
| CCND1 | -2.15 | 8.7e-09 | 2156 | Down |
| MYC | -1.94 | 3.2e-07 | 1876 | Down |
Pathway Scores
UPR / ER Stress
████████░░ 0.87
Apoptosis
██████░░░░ 0.64
Cell Cycle
████░░░░░░ 0.41